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You may also find it helpful to learn about all known breast cancer risk factors and ovarian cancer risk factors in addition to those that are genetic. About 5 to 10 percent of people diagnosed with breast cancer have inherited an increased risk of developing the disease. In these cases, breast cancer runs in the family. Similarly, 5 to 10 percent of ovarian cancers diagnosed are hereditary.
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When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. People who have inherited mutations in BRCA1 and BRCA2 tend to develop breast and ovarian cancers at younger ages than people who do not have these mutations. Like women from the general population, those with harmful BRCA1 or BRCA2 mutations also have a high risk of developing a new primary cancer in the opposite contralateral breast in the years following a breast cancer diagnosis. Ovarian cancer: About 1.
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Women who have inherited mutations in these genes are at an increased risk of developing breast cancer and ovarian cancer compared with the general population. The BRCA gene test is offered only to people who are likely to have an inherited mutation based on personal or family history, or who have a specific type of breast cancer. The BRCA gene test isn't routinely performed on women at average risk of breast and ovarian cancers. If you do, your result is positive and your doctor can help you understand your cancer risk.
Skip to Content. The chance that a family has HBOC increases in any of these situations:. A woman is diagnosed with a second breast cancer in the same or the other breast or has both breast and ovarian cancer.
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